A green and efficient method for the preparation of 3, 4-dihydropyrimidin-2(1H)-ones using quaternary ammonium- treated clay in water

Document Type : Original Paper


1 1Chemistry Department, Mahshahr Branch, Islamic Azad University, Mahshahr

2 Chemistry Department, Omidieh Branch, Islamic Azad University, Omidieh, Iran


In this study, a variety of 3, 4-dihydropyrimidin-2(1H)-ones derivatives were synthesized via three-component Biginelli reaction. The quaternary ammonium- treated clay -catalyzed process proved to be simple, efficient, and environmentally friendly.