Synthesis of alkyl 2-(4-oxoquinazolin-3(4H)-yl) acrylate by nucleophilic additionof alkyl propiolates catalysed by Ph3P

Document Type : Original Paper

Authors

Department of Organic Chemistry, Karaj Branch, Islamic Azad university, Karaj, Iran

Abstract

4-Hydroxyquinazoline undergoes neutral conditions with alkyl propiolates in the presence of triphenylphosphine (0.26g), and by α substituation the corresponding  2-(4-oxoquinazolin-3(4H)-yl acrylate was obtained in good yields.

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