Kiasat, A., Nikmanesh, M. (2012). One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar. International Journal of Heterocyclic Chemistry, 2(3), 20-27.
Alireza Kiasat; Maryam Nikmanesh. "One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar". International Journal of Heterocyclic Chemistry, 2, 3, 2012, 20-27.
Kiasat, A., Nikmanesh, M. (2012). 'One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar', International Journal of Heterocyclic Chemistry, 2(3), pp. 20-27.
Kiasat, A., Nikmanesh, M. One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar. International Journal of Heterocyclic Chemistry, 2012; 2(3): 20-27.
One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar
Department of Chemistry , Shahid Chamran University , Ahwaz , Iran
Abstract
phenytoine derivatives were synthesized , via the pinacol condensation with the reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea in presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle at room temperatures. The reaction was completed at short reaction times (approximately 15min) and pure products were obtained with high yields (81-94%).
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