Document Type: Original Paper
Department of Chemistry , Firoozabad Branch, Islamic Azad University,Firoozabad, Iran
Department of Chemistry , Firoozabad Branch, Islamic Azad University, Firoozabad, Iran
An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.