Alinezhad, H., Ghobadi, N. (2012). Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions. International Journal of Heterocyclic Chemistry, 3(1), 1-8.
Heshmatollah Alinezhad; Neda Ghobadi. "Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions". International Journal of Heterocyclic Chemistry, 3, 1, 2012, 1-8.
Alinezhad, H., Ghobadi, N. (2012). 'Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions', International Journal of Heterocyclic Chemistry, 3(1), pp. 1-8.
Alinezhad, H., Ghobadi, N. Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions. International Journal of Heterocyclic Chemistry, 2012; 3(1): 1-8.
Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions
Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Abstract
An efficient and convenient procedure for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones by condensation of 1,3-dicarbonyl compounds, Aromatic and aliphatic aldehydes, and urea or thiourea in the presence of catalytic amount of Brønsted acidic ionic liquid 3-methyl-1-sulfonic acid imidazolium chloride {[Msim]Cl} under thermal solvent-free conditions reacted easily to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones and thiones. Straightforward and clean workup, short reaction time, good to excellent yields and reusability of the catalyst are the advantages of this method.
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