One-Pot Synthesis of Phenytoin Analogs in soilution Conditions

Document Type: Original Paper

Authors

Department of Chemistry , Shahid Chamran University , Ahvaz , Iran

Abstract

phenytoine derivatives were synthesized , via the pinacol condensation with the
reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea
in presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle at
room temperatures. The reaction was completed at short reaction times (approximately
15min) and pure products were obtained with high yields (81-94%).

Keywords