Microwave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives

Document Type: Original Paper

Authors

1 Factually of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.

2 Medicinal & Natural Products Chemistry Research Center , Shiraz University of Medical Sciences , Shiraz , Iran

3 Factually of science , Ahvaz Branch Islamic Azad University , Ahvaz , Iran .

Abstract

New pyrimido [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazines were synthesized via the cyclocondensation of alkyl-2-phenylhydrazinecarbodithioates as a binucleophile with 5-bromo-2,4-dichloro-6-methylpyrimidine as a bielectrophile , and replacement of C-7 chloro atom by hydrazine in ethanol as the solvent . This method has advantages over methods currently described in the literature for the construction of such heterocyclic ring systems.

Keywords


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