Uranyle Complexes: synthesis, evaluation of biological activity

Document Type: Original Paper


1 Department of Chemistry, Faculty of Science, Imam Khomeini International University,Ghazvin, Iran

2 Department of Chemistry, Faculty of Science, Imam Khomeini International University, Ghazvin, Iran

3 Department of Hematology, Faculty of Medicine, Tarbiat Modarres University, P.O. Box, Tehran, Iran


In this research, some of the inorganic complexes of uranyl with N- donor ligands
were synthesized. Complexes were characteriezed by FT-IR and UV spectra, ¹HNMR,
¹³CNMR and some physical properties. The uranyl unit (UO2) is composed of a center of
uranium atom with the charge (+6) and two oxygen atom by forming two U=O double bonds.
The structure is linear (O=U=O, 180) and usually stable. So other ligands often coordinate to
the U atom in the plane perpendicularly to the O=U=O axis. The antitumor activity of some of
ligand and their complexes against a panel of human tumor cell lines (HT29: Haman colon
adenocarcinoma cell line T47D: human breast adenocarcinoma cell line) were determined by
MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay. These data
suggest that some of these compounds provide good models for the further design of potent
antitumor compounds.


[1] X. F. Luo, X. Hu, X. Y. Zhao, S. H. Goh, and X. D. Li, Miscibility and interactions in
blends and complexes of poly(4-methyl-5-vinylthiazole) with proton-donating polymers,
Polymer., 44, ( 18), 5285–5291(2003).
[2] A. S. N. Murthy and A. R. Reddy, Electronic absorption spectroscopic studies of
enolimine-ketoamine equilibria in Schiff bases, J. of Chem. Scie., 90( 6), 519–526(1981).
[3] V. Razakantoanina, N. K. P. Phung, and G. Jaureguiberry, Antimalarial activity of new
gossypol derivatives, Parasitology. Res., 86( 8), 665–668(2000).
[4] R. E. Royer, L. M. Deck, T. J. Vander Jagt, et al, Synthesis and anti-HIV activity of 1,1_-
dideoxygossypol and related compounds, J. of Med .Chem., 38(13), 2427–2432( 1995).
[5] M. R. Flack, R. G. Pyle, N. M. Mullen, et al, Oral gossypol in the treatment ofmetastatic adrenal cancer, J. of Clin. Endoc & Meta., 76, (4), 1019– 1024(1993).
[6] R. Baumgrass, M. Weiwad, F. Erdmann, et al, Reversible inhibition of calcineurin by the
polyphenolic aldehyde gossypol, J. of Biolog. Chem., 276( 51) 47914–47921( 2001).
[7] M. B. Teimouri and R. Bazhrang, Shaken not stirred: a facile synthesis of 1,4-bis(furo[2,
3, d]-pyrimidine-2,4(1H, 3H)- dione-5-yl)benzenes by one-pot reaction of isocyanides, N,N_-
dimethylbarbituric acid, and terephthaldialdehyde, Bioorg & Med. Chem .Lett., 16( 14),3697–
[8] M. B. Teimouri, One-pot three-component reaction of isocyanides, dialkyl
acetylenedicarboxylates and phthalhydrazide: synthesis of highly functionalized 1Hpyrazolo[1, 2− b]phthalazine-5,10-diones, Tetrahedron., 62( 47), 10849–10853( 2006).
[9] J. V. Metzger, A. R. Katritzky, W. Rees, and K. T. Potts, Eds, Compr. Hetero. Chem., 6, Pergamon, Oxford, UK, 1984.
[10] J.M.Grevy, F. Tellez, S. Bern´es, H. N¨oth, R. Contreras, and N. Barba-Behrens,
Coordination compounds of thiabendazole with main group and transition metal ions, Inorg.
Chimi. Acta., 339, 532–542(2002).
[11] A. Bernalte-Garc´ıa, F. J. Garc´ıa-Barros, F. J. Higes-Rolando, and F. Luna-Giles,
Coordination chemistry of thiazoline/ thiazolidine derivatives. I: crystal structure of 2-(2-
pyridyl)imino-N-(2-thiazolin-2-yl)thiazolidine (PyTT) and study of its interaction with
nickel(II), Polyhedron., 18( 22), 2907–2912( 1999).
[12] K. Lemma, J. Berglund, N. Farrell, and L. I. Elding, Kinetics and mechanism for
reduction of anticancer-active tetrachloroam( m)ine platinum(IV) compounds by glutathione,
J. of Biolog. Inorg. Chem., 5( 3), 300–306( 2000).
[13] M. J. M. Campbell, Transition metal complexes of thiosemicarbazide and
thiosemicarbazones, Coordin. Chem. Rev., 15, ( 2-3), 279 319(1975).
[14] S. Padhy´e and G. B. Kauffman, Transition metal complexes of semicarbazones and
thiosemicarbazones, Coordin. Chem. Rev., 63,127–160, (1985).
[15] B. Erwin and C. Omoshile, Hydrogen isotope exchange in PtII-thiazole complexes, J. of
the Chem. Soc. Per. Trans., 2, 1333–1338(1995).
[16] G. Zhao, H. Lin, S. Zhu, H. Sun, and Y. Chen, Dinuclea palladium(II) complexes
containing two monofunctional [Pd(en)(pyridine)Cl]+ units bridged by Se or
S. Synthesis, characterization, cytotoxicity and kinetic studies of DNAbinding, J. of Inorg. Biochem., 70( 3-4), 219–226(1998).