Effiecient Synthesis of tetrazoloquinoxaline derivatives

Document Type: Original Paper

Authors

Department of Chemistry, School of Sciences, Ahvaz Branch, Islamic Azad University, Ahvaz 6134968875, Iran.

Abstract

Displacement reaction of 2,3-dichloroquinoxaline with secondary amines in boiling ethanol afforded it`s mono aminoquinoxaline derivatives. Further reaction of the latter compounds with sodium azide in warm dimethylsulfoxide achieved a group of 4-amino tetrazolo[1,5-a]quinoxaline derivatives. 1HNMR spectra of these compounds are discussed.

Keywords


[1] Bakavoli, M., M. Nikpour, , Rahimizadeh, M., Saberi, M.R., Sadeghian, H., Bioorganic and Medicinal Chemistry 15 (5), pp. 2120-2126 (2007).
[2] Bakavoli, M., Sadeghian, H., Tabatabaei, Z., Rezaei, E., Rahimizadeh, M., M. Nikpour, , Journal of Molecular Modeling 14 (6), pp. 471-478 (2008).
[3] Mirzaei, M., Chen, Y.-G., Kaju, A.A., Bakavoli, M., Inorganic Chemistry Communications 12 (9), pp. 879-882 (2009).
[4] M. Nikpour, H. Sadeghian,, M. R. Saberi, R. Shafiee N., S. M. Seyedi, A. Hosseini, H. Parsaee, A. Taghian D. B., Bioorganic & Medicinal Chemistry 18, pp. 855–862 (2010).

[5] M. Mirzaei, A. Aghaei K., Ya Guang Chen, S. Zarinabadi, Chinese Chemical Letters 21, pp. 501–505 (2010).
[6] J. Azizian, R. Miri, M. K. Mohammadi, F. Sheikholeslami F., J. Hosseini, M. Nikpour, Phosphorus, Sulfur and Silicon and the Related Elements, 185, 1782-1787, (2010).
[7] S. Wagle, A. V. Adhikari and N. S. Kumari, Europian Journal of Medicinal Chemistry, 44, 1135-1149 (2009).
[8] Barry A. Dreikorn and Thomas D. Thibault, US Patents, 3, 979, 387, Sept. 7, 1976.