Synthesis of Some Quinazoline Derivatives Functionalized with3-Heterocycles Side Chain

Document Type: Original Paper

Authors

1 Department of Chemistry, College for Girls, Ain Shams University, Helioplis, Cairo 11457, Egypt

2 Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt

Abstract

Utilization of benzoxazinone for synthesis quinazolinone derivatives with 3-heterocycle side chain. treatment of benzoxazinon 1 with cyano acetohydrazide or thionocarbohydrazide gave the quinazolinone derivatives 2 or 12. quinazolinone 2 has been utilized as synthon for new  pyridinone, oxazet, thiazole, thiazolidinone and quinazolinone derivatives. Thiosemicarbazide and thiosemicarbazone derivatives are synthesized from quinazolinone 12 by different route. The structures of the new compounds were established on the basis of IR, 1HNMR, mass spectral data, and elemental analysis.

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