Ezabadi, A., Tosan, F. (2018). A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition. International Journal of Heterocyclic Chemistry, 8(3), 5-11.
Ali Ezabadi; Fatemeh Tosan. "A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition". International Journal of Heterocyclic Chemistry, 8, 3, 2018, 5-11.
Ezabadi, A., Tosan, F. (2018). 'A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition', International Journal of Heterocyclic Chemistry, 8(3), pp. 5-11.
Ezabadi, A., Tosan, F. A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition. International Journal of Heterocyclic Chemistry, 2018; 8(3): 5-11.
A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
1Department of Chemistry, Faculty of Sciences, Islamic Azad University, Central Tehran Branch, Iran
2Department of Chemistry, Faculty of Sciences, Islamic Azad University, Central Tehran Branch, Iran
Abstract
An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields.
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