Alinezhad, H., Ghobadi, N. (2018). Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions. International Journal of Heterocyclic Chemistry, 8(3), 41-48.
Heshmatollah Alinezhad; Neda Ghobadi. "Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions". International Journal of Heterocyclic Chemistry, 8, 3, 2018, 41-48.
Alinezhad, H., Ghobadi, N. (2018). 'Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions', International Journal of Heterocyclic Chemistry, 8(3), pp. 41-48.
Alinezhad, H., Ghobadi, N. Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions. International Journal of Heterocyclic Chemistry, 2018; 8(3): 41-48.
Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions
1Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
2Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran,
Abstract
An efficient and convenient procedure for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones by condensation of 1,3-dicarbonyl compounds, Aromatic and aliphatic aldehydes, and urea or thiourea in the presence of catalytic amount of Brønsted acidic ionic liquid 3-methyl-1-sulfonic acid imidazolium chloride {[Msim]Cl} under thermal solvent-free conditions reacted easily to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones and thiones. Straightforward and clean workup, short reaction time, good to excellent yields and reusability of the catalyst are the advantages of this method.
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