Solvent Free Synthesis of tetra alkyl- phenyl-1H-pyrimido [4, 5-e][1,3,4]Thiadiazine-3,7-diamines

Document Type : Original Paper

Author

• mohammad kazem mohammadi

Department of chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

Keywords

• New 1
• 5-tetra alkyl methyl- phenyl-1H-pyrimido[4
• 5-e][1
• 4]thiadiazine-3
• 7-diamine were synthesized via the cyclocondensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate and further replacement of chlorine atom on the seven number position of pyrimido[4
• 5- e][1
• 3
• 4]thiadiazin by appropriate secondary amines in simple and efficient methods