Efficient Synthesis of Thiazolo[4,5-d]pyrimidine derivatives without solvent

Document Type : Original Paper

Author

Department of Chemistry, School of Sciences, Ahvaz Branch, Islamic Azad University, Iran

Abstract

4-Amino-5-bromo-2-substituted-aminopyrimidines were successfully reacted with various isothiocyanates in the alkaline alumina under Microwave irradiation to achieve a group of reported 2- aminothiazolo[4,5-d]pyrimidine derivatives . These compounds also carried out a multicomponent condensation with carbondisulfid and alkylhalides to furnish a group of reported 2- alkylsulfanylthiazolo[4,5-d]pyrimidine derivatives.

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