Solvent Free Synthesis of tetra alkyl- phenyl-1H-pyrimido[4,5-e][1,3,4]Thiadiazine-3,7-diamines

Document Type : Original Paper


Department of Chemistry, Firuzabad Branch, Islamic Azad University, Firuzabad, Iran.


New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine  were synthesized via the cyclocondensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate  and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 3, 4]thiadiazin by appropriate secondary amines  in simple and efficient methods.